Methotrexate is an anti-inflammatory agent used to treat rheumatoid arthritis and other inflammatory conditions. Although methotrexate does not cause increased susceptibility to infections, your doctor may want to stop methotrexate if you develop a serious infection. People with newly-developed rheumatoid arthritis or undifferentiated arthritis may be able to achieve remission, with continued drug therapy, after four months of treatment with methotrexate and prednisone, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in Atlanta. Dosages of 15 to 25 mg of prednisone per day can reduce inflammation considerably, although many patients relapse when therapy is tapered.
Rheumatoid arthritis (RA) is a serious disease that can lead to permanent disability from joint destruction.
Polymyalgia rheumatica (PMR) is a chronic, self-limited disorder. A majority (63%) of patients with rheumatoid arthritis and undifferentiated arthritis who take initial combination therapy consisting of methotrexate and low-dose prednisone achieved early remission.
In contrast to anabolic steroids (used by “bodybuilders”), corticosteroids are used in inflammatory conditions for their anti–inflammatory effects. PREDNISONE AND LEUKOCYTOSIS
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